Elucidating mechanism of drug induced toxicity hoehn upgraded mary beth

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A study was conducted to determine if cocaine and acetaminophen toxicity lead to DNA damage and to the activation of the repair protein, PARP in the liver using the hepatotoxicants: cocaine and acetaminophen (APAP).A dose-response analysis for cocaine concluded that a dose as low as 20 mg/kg resulted in elevated ALT levels.Results The study enrolled from October 2009 to March 2011.Median age was 32.5 months; sex distribution was equal.The PARP inhibition analysis for cocaine and APAP was conducted at 6 and 18 hours post initial dose, respectively, when the highest levels of PARP were observed.

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The dose-response analyses for APAP resulted in no elevated liver enzyme levels for a 75 mg/kg and 150 mg/kg dose.DIQ was effective in reducing drug-induced hepatotoxicity and preserving organ function.The cornerstone of tuberculosis management is a 6-month course of isoniazid, rifampicin, pyrazinamide and ethambutol. Adverse effects often negatively affect the compliance, because they frequently require a change of treatment, which may have negative consequences for treatment outcome.Microbiological confirmation of disease was made in 6 %.Baseline characteristics associated with death included convulsions (HR 3.46, 95CI 1.19–10.13, p = 0.02), decreased consciousness (HR 22.9, 95CI 3.01–174.3, p 5 years) and hydrocephalus were also associated with the combined endpoint of death or disability.

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